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1 Like most complex genomic regulatory systems, Nrf2 (nuclear factor erythroid 2-related factor 2) is sequestered in the cytoplasm until it is able to translocate into the nucleus, where it forms a heterodimer with MAF (another transcription factor) and binds to the promoter region of genes containing an antioxidant response element (ARE) sequence

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doi: 10.1056/NEJMra1413352 188 Sanie-JahromiFMahmoudiAKhaliliMRNowroozzadehMH

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Camara-Lemarroy CR, Salas-Alanis JC

Mice heterozygous for the oxytocin receptor gene (Oxtr +/- ) show impaired social behavior but not increased aggression or cognitive inflexibility: evidence of a selective haploinsufficiency gene effect