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Proglucagon is stored in intracellular granules where it undergoes post-translational processing and is cleaved by prohormone convertase 1/3 to produce peptides such as GLP-1 (Orskov et al., 1986)

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Remember, it's important to adhere to the prescribed dose and duration of treatment for the best results

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In the context of MASLD/MASH, analogous rebound phenomena would be expected: regression of achieved steatosis resolution and potential re-emergence of inflammatory activity and fibrogenic stimuli upon drug withdrawal