Efficacy and safety of growth hormone (GH) in the treatment of adult Japanese patients with GH deficiency: A randomised, placebo-controlled study
While shifts in carbohydrate, amino acid and lipid metabolism indicate altered substrate utilization under nutrient-limited conditions, direct impacts on cellular energy status cannot be inferred, as changes in adenylic nucleotides, phosphagens, and cellular energy charge were not detected in this study
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For this purpose, cells were harvested, pipetted into a 96-well OptiPlate (6000 cells/well) and stimulated with different concentrations of -MSH or PG-901 for 30 min
It is a recombinant form of the peptide exendin-4, which is a GLP-1 receptor agonist with a 53% similarity to the gastrointestinal hormone GLP-1 and it is resistant to DPP-4 inactivation with a 140-minute half-life after subcutaneous administration allowing therapy by a twice daily administration [36]