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An enzyme based theory of obligate anaerobiosis: the physiological function of superoxide dismutase

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Excess generation of reactive oxygen species (ROS) in the form of superoxide anions, hydrogen peroxide, and hydroxyl radicals can cause extensive damage to cellular macromolecules

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While our study is currently limited by the availability and quality of sex-specific information across public databases, ongoing efforts to improve data annotation and increase the representation of both sexes in transcriptomic studies will progressively strengthen future analyses