These doses are sub-therapeutic, meaning they fall below the level that clinical trials have demonstrated to produce statistically significant weight loss
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Additionally, if you experience symptoms like severe abdominal pain, blood in stools, or unexpected weight loss, seeking immediate medical attention is important
Nausea, bloating, digestive discomfort, and gastroparesis can make adherence difficult
For researchers weighing over 300 pounds (136 kg), the standard 4-week escalation is typically well tolerated, and the 12mg maintenance dose is strongly recommended
However, this should only be a short-term option