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Think about what that muscle loss actually means in practice

That is one of the main reasons this medication has created so much momentum compared with earlier generations of obesity treatment

PMID 11031273

Endocrinol.: The maintenance of long-term weight loss after semaglutide withdrawal in obese women with PCOS treated with metformin: a 2-year observational study Medscape: Help Patients Prevent Weight Gain After Stopping GLP-1s

Your body is working hard to adjust to the medication and metabolic changes, which can contribute to a feeling of low energy

Some studies indicate that this combination may provide metabolic improvements compared to either agent alone, though more robust clinical trials are needed to confirm these findings and determine the magnitude of effects