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APAP overdose leads to excessive generation of the highly reactive metabolite n-acetyl-p-benzoquinone imine (NAPQI), which depletes glutathione (GSH), increases oxidative stress, and causes mitochondrial dysfunction, finally triggering immune response-mediated hepatotoxicity and massive hepatocytes necrosis [15, 16]
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Think of oxidative stress as "biological rusting." Just as oxygen can cause metal to rust over time, free radicals can wear down the integrity of our skin cells, leading to signs of aging and uneven tone
Mikshta et al
This means injections should be administered only by qualified clinicians, and patients need to be fully informed
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