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5 Journal of Orthopaedic ResearchChang CH et al

Saudi Journal of Kidney Diseases and Transplantation

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Summary: There is no authorised UK reconstitution ratio for retatrutide, as it remains an unlicensed investigational compound with no approved MHRA guidance, SmPC, or NHS prescribing pathway

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If a patient is deemed high-risk, it is safer to prescribe the medication cautiously only after fully explaining the potential risks, such as depression or suicidal ideation, to the patient or caregiver and obtaining consent for continuous monitoring