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~ 33 min SC half-life Subcutaneous half-life documented by Dorr et al

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Notably, pancreatic Glp1r expression was unchanged, whereas Glp1r expression was markedly reduced in lung tissue from Glp1r Tie2/ mice (Figure 1C)

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This metabolite acts as an agonist of the N-methyl-D-aspartate (NMDA) receptor, and its increase can lead to excessive activation of such receptors, causing increased calcium entry into neuronal cells and consequently neuronal damage through excitotoxicity mechanisms