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We have indicated that male mice could also successfully establish NTG induced CM model [17, 18], it is well known that sex differences in migraine is mainly due to the role of estrogen [44, 45], thus, to avoid the influence of estrogen, we selected male mice for further study

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[8] In the swine part of the study, Ipamorelin did not produce ACTH or cortisol levels significantly different from the GHRH comparison group under the tested conditionsthe comparator was the GHRH group, not a baseline-untreated controleven at tested doses more than 200 times its GH ED 50

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