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Additionally, the relevant effect of GLP-1R signaling on blood pressure control may be attributable to the action of agonists on sodium reabsorption in the proximal tubule, and interference with intrarenal angiotensin II, thus augmenting renal blood flow and promoting natriuresis (Jensen et al., 2020
In the PIONEER 6 trial, hypoglycemia was reported in 1.4% of patients using oral semaglutide compared to 0.8% in the placebo group
Our findings warrant further investigation of the potential preventive effect of GLP-1RAs against prostate cancer risk
Several mechanisms have been proposed, including inhibition of free fatty acid release from adipose tissue, increased lipoprotein lipase activity, decreased triglyceride synthesis, decreased VLDL-triglyceride transport, and an inhibition of lipolysis
Parry CH
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