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Promote the proliferation or increase the reproduction of pancreatic beta cells, which produce insulin GLP-1 receptor agonists may also restore the body's insulin-secretion function in the pancreas, which can contribute to improvements in glucose regulation and body weight reduction in those with diabetes
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Draft scope post-referral: retatrutide technology appraisal GID-TA11525
These are considered beneficial cardiovascular effects
Quick Answer: Semaglutide is FDA-approved for chronic weight management without a specified maximum treatment duration, and patients may continue therapy indefinitely as long as they respond well and tolerate the medication
In Weighing the Impacts of GLP-1s: Quasi-Experimental Evidence from Provider Adoption (NBER Working Paper 34667), Sam Bock, Jasmin Moshfegh, and Jonathan Zhang study 1.4 million veterans who were diagnosed with diabetes or obesity and who received care through the Veterans Health Administration (VHA)
