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In the fibrotic context, metabolic pathways driven by specific amino acids directly support cellular proliferation, differentiation, and excessive ECM deposition, which are hallmark features of fibrogenesis

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Cobalamin deficiency is more common amongst the elderly

These influences include geographic factors like access to healthy food, green space, and healthcare, as well as socioeconomic status, chronic stress, discrimination, and environmental pollution

Medications that compete with phenytoin for binding to albumin (e.g., valproic acid)

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