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The most common side effects are acid reflux, constipation, fatigue, headaches, indigestion, mild nausea, and vomiting, which Saleh says are often eliminated or lessened as the medication stays in the body and you shift your lifestyle and eating habits. To minimize these side effects, avoid foods that are spicy or high in fat, and eat smaller, more frequent meals

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Rarely, persistent gastrointestinal symptoms may indicate that semaglutide is not the right medication for you, or that an underlying condition (such as irritable bowel syndrome or lactose intolerance) is being unmasked by the slower digestion the drug creates