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If it goes into tissue with more blood flow, then it will be absorbed and distributed too quickly

[5] [6] When these agents are used together, there is a theoretical risk of unpredictable glycaemic fluctuations, particularly in individuals with pre-existing impaired glucose tolerance or type 2 diabetes

Prevalence of small intestinal bacterial overgrowth in Parkinsons disease

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5 A number of reasons have been suggested for this lack of efficacy in certain individuals, ranging from genetic mutations causing poor responses to pharmacokinetic differences and concomitant medical conditions