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This lack of absolute specificity raises concerns about off-target effects, particularly given the potential for unintended gene activation in noncardiac tissues

[35] Thus, drug delivery systems containing disulfide bonds, typically cross-linked micro-nanogels, stand out for their ability to degrade in the presence of high concentrations of glutathione (GSH)

For a while it was thought that the GLP-2 moiety was an evolutionary late addition to the gene, since fish and bird proglucagon appeared to contain only a single glucagon-like peptide corresponding to GLP-1 (172)

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