doi:10.1016/j.bcp.2019.02.008 Dimet-Wiley A, Latham CM, Brightwell CR, et al
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The split-dose protocol used by many compounding telehealth clinics is intended to smooth the Cmax peak that drives nausea: tirzepatide has a roughly 120-hour half-life (StatPearls pharmacokinetics) and once-weekly dosing produces a peak 8 to 72 hours post-injection where GI side effects cluster
If they resolve, the peptide may simply not be right for you