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Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG
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Clinical trials have used doses of 25-30 nmol/kg by IV infusion (Schneider-Helmert et al., 1981Subcutaneous administration and oral intestinal absorption have also been studied
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USA 87 , 728732 (1990)
Minimally Invasive Unlike surgery, which involves incisions and lengthy recovery periods, peptide therapy is a minimally invasive option that can be administered via injections or oral supplements
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