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Niacinamide: visually smooths the skins surface, reduces the visibility of pores, and strengthens the protective epidermal barrier

The four-pathway model therefore targets appetite (GLP-1 and amylin through separate neuronal circuits), fat metabolism (GIP and glucagon), energy expenditure (glucagon primarily), and glucose homeostasis (GLP-1, GIP, and amylin all contribute through different mechanisms)

Physiological Reviews , 91(4), 1409-1439

and now provide a concise, cited synthesis

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These are generally mild and transient