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Weight loss, especially rapid or substantial weight loss, can influence the menstrual cycle

One network meta-analysis estimated the efficacy of SGLT2is, compared with nsMRAs, and spironolactone or eplerenone

Suitable for active and fitness-focused lifestyles

Fiber intake Soluble fiber gets fermented by gut bacteria into short-chain fatty acids, particularly butyrate, which directly stimulates GLP-1 secretion from intestinal L-cells

Elevated intracellular iron can saturate NMs binding sites, causing iron release from low-affinity sites and enhancing iron-driven oxidative stress (128)

It is not indicated for type 1 diabetes or for diabetic ketoacidosis