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Increased barrier permeability may be the first step in the development of various disorders, or be a cause of their progression, not only in gastrointestinal disease

Anxiety about whether the new medication will work, frustration during retitration periods when appetite returns, and the cognitive load of tracking two different dosing protocols all take a psychological toll

Assessment of cardiovascular risk factors and kidney function, which may affect dosing

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The growth phase lasts longer as a result