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Although previous studies have largely assigned depressive symptoms to the three monoamine neurotransmitters (dopamine, norepinephrine, or serotonin), we describe a specific peripheral glutamatergic dysfunction (decreased GDH activity in K2 relatively control) that accompanies distinct clinical DE phenotypes with a predominance of parkinsonian neurological symptoms
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10.1056/NEJMoa1509225 77 PsichasA.SleethM
3.1 Tirzepatide effects: glucose lowering effects of tirzepatide Tirzepatide, a once-weekly subcutaneous injection, was FDA approved in May 2022 as an adjunct treatment with diet and exercise to improve glycemic control in adults with Type 2 diabetes [43]
Jiao et al
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