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It reduced lines and wrinkles, improved skin density, and increased skin thickness better than both placebo and vitamin K cream

The rash usually worsens significantly during the first one to two weeks before any improvement appears

Hadley et al., Discovery and development of the novel melanogenic drugs, in Integration of Pharmaceutical Discovery and Development: Case Studies, edited by Borchardt et al., Plenum Press, New York (1998)

Mazzatenta A, Pokorski M, Sartucci F, et al

The recommended dose may range from 1 to 5 mL, depending on the concentration of each vitamin component and the desired therapeutic effect

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