The longer window for biologics was a concession to biologic manufacturers concerned that negotiation would undercut the 12-year exclusivity period established by the BPCIA
To uncover the underlying mechanisms, the researchers analyzed hippocampal tissue focusing on dentate gyrus, where they quantified neural progenitor proliferation and neurogenesis through BrdU, immunofluorescence for Sox2, GFAP, DCX and NeuN, and unbiased stereological cell counting
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A peptide stable for weeks at 4 degrees Celsius may degrade within days at room temperature in solution
This structural failure results in the hallmark blood pooling and compensatory tachycardia of POTS
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