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Impact of interval and combination therapies on the management of actinic keratosis: review and clinical considerations

Several studies have shown that complete withdrawal of an obesity treatment dose of a GLP-1RA without other structured care leads to weight regain in most people.2 However, it remains unclear whether lifelong treatment of obesity should always consist of GLP-1RAs at full obesity dosing or whether a range of alternative strategies can enable some subset of people with obesity to maintain their weight loss after a limited duration of initial treatment, followed by tapering, discontinuing, or off-ramping these agents." This paragraph from the article, I believe, sums up nicely what this means

its a physiological reality

There is a need for more specific guidelines tailored to the unique characteristics of different Asian populations

Multiple studies have shown people regaining weight after stopping GLP-1 medications

doi: 10.2174/1570159X21666221228095256