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Each of these 3 incretins have somewhat different effects, both at the gut level and via the brain, regarding reduced appetite, increased energy expenditure, nutrient storage and substrate utilization, insulin secretion, promotion of satiety, delay of gastric emptying, or reduced systemic inflammation

Chen H, et al

MARCKS phosphorylation and amylase release in GLP-1-stimulated acini isolated from rat pancreas

Appetite reduction is common

Wegovy and Saxenda can help kickstart the process, but your daily efforts will determine how effective and lasting your weight loss journey will be

They need to be metabolized to work, Dr