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Clinical evaluation included daily assessment of lameness, defined as the inability of the rabbit to bear weight and maintain the typical flexion-extension cycle of the affected limb compared to the unaffected limb

An FDA warning letter states that AOD-9604 is not a component of an FDA-approved human drug

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While formal pharmacokinetic parameters (Cmax, AUC, t1/2) have not been published in peer-reviewed literature for oral dosing in humans, its low molecular weight (173 Da), positive charge, and water solubility support intestinal absorption

Diagnosis and treatment of hyponatraemia