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Conversely, treatment with Ferrostatin-1 (Fer-1) or Acteoside, both ferroptosis inhibitors, significantly attenuated SAL-induced ferroptosis and neuronal injury (Wang et al., 2025b)

Data availability The data in this study will be made publicly available according to publication date in the Gene Expression Omnibus (GEO) under accession no

NUPR1: a critical regulator of the antioxidant system

Receptor-knockout mouse models are the standard tool for this dissection in the literature: single- and double-knockout backgrounds attenuate Retatrutides body-weight effect in a stepwise pattern consistent with a three-receptor mechanism, while Tirzepatides effect maps more directly onto its two targets

doi: 10.1016/j.cmet.2020.07.013 77 CoriCFCoriGT

This is one of the reasons diets rich in whole plant foods, resistant starches and complex fibres are consistently associated with better metabolic health and improved blood-sugar regulation