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Any theoretical combination would likely require substantially reduced doses of both compoundsperhaps 1.2-2.4 mg cagrilintide with 4-8 mg retatrutide as maximum limits, though even these suggestions are purely speculative

Karchoubi F, Afshar Ghotli R, Pahlevani H, Baghban Salehi M

This study aimed to compare the impacts of starting GLP-1-RAs versus dipeptidyl peptidase-4 inhibitors (DPP-4is), like linagliptin (Tradjenta) on the risk of heart attacks, strokes, and death among patients with various autoimmune diseases and type 2 diabetes

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Madani H, Asgari S, Naderi GA

Semaglutide is a GLP-1 (glucagon-like peptide-1) receptor agonist, meaning it mimics a hormone naturally produced in your gut