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The trade-off is the fixed 5:1 ratio: you cannot raise one compound without raising the other

Benzyl alcohol has been associated with serious adverse events and death in pediatric populations, particularly neonates, due to: Immature metabolic pathways for benzyl alcohol detoxification Accumulation of benzyl alcohol and its metabolite (benzoic acid) Gasping Syndrome characterized by metabolic acidosis, gasping respirations, CNS depression, and cardiovascular collapse For neonatal research applications, use only preservative-free Sterile Water for Injection

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There are theoretical concerns, like a potential connection to cancer, that can't be dismissed without more research