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Tan X, Kong D, Tao Z, et al
Abstract Renal ischemiareperfusion injury (RIRI) is a prevalent and damaging pathological process in clinical practice, significantly impairing renal recovery and long-term prognosis
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To investigate whether albumin could be engineered to evade L585 cleavage and the resulting reduction in FcRn binding, we constructed a panel of 18 full-length 585-engineered human albumin variants, in which the C-terminal leucine residue was substituted with each of the other naturally occurring amino acids, except for cysteine (Fig
The third interaction is between the side chain of L56 (C1) and the carbon atom of the acetamide group
