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Absolute Contraindications Do not use GLP-1 and dual GIP/GLP-1 medications if you have any of the following: A personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN2) A history of pancreatitis or symptomatic gastroparesis Severe gastrointestinal disease Pregnant or planning pregnancy Final Thoughts GLP1 and dual GIP/GLP1 receptor are now widely used to help manage type 2 diabetes and obesity

Its worth noting that most treatment discontinuations occurred during the rapid dose-escalation phase, suggesting that a more gradual dose-escalation strategy could potentially mitigate these issues

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