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The bio-availability of the DPP-4 inhibitors is very good and the pharmacodynamic- as well as the pharmacokinetic characteristics lead to the above mentioned clinically sufficient DPP-4 inhibition with once daily dosing (only vildagliptin has to be dosed twice daily) (18, 19)
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Effective cancer therapies should therefore focus on both restoring wild-type p53 function and targeting the oncogenic signaling pathways activated by mutant p53
Carnitine and Endometriosis I recently received a question from a reader about the connection between endometriosis and carnitine
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It modifies the skin barrier (stratum corneum): by altering the lipid structure of the skins stratum corneum, it increases skin permeability, aiding drug penetration to deeper tissues
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