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The GLP-1 CVD outcome trials a) Elixa (Lexisenatide) b) Leader (Liraglutide) c) Sustain-6 (Semaglutide) d) Exscel (Weekly Exenatide) e) Harmony (Albiglutide) f) Rewind (Dulaglutide) g) Pioneer 6 (Oral Semaglutide) Elixa Study (Evaluation of Lixisenatide) In ELIXA, the investigational GLP-1 receptor agonist, lixisenatide, neither reduced nor increased cardiovascular events compared with placebo
Consistent with previous reports, nearly 2/3s of DMP-associated genes in this study were involved in the dysregulation of type I/II IFNs or both
For example, in the context of clear cell renal cell carcinoma development, loss of SDH genes has been shown to dampen oxidative phosphorylation and reduce susceptibility to ferroptosis 112
Kim YM et al
[2] Wu JC, Tsai HE, Hsiao YH, Wu JS, Wu CS, Tai MH