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In: Proceedings of the 1974 Laurentian hormone conference, Elsevier, pp 487532 Dupre J, Ross S, Watson D, Brown J (1973) Stimulation of insulin secretion by gastric inhibitory polypeptide in man

Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Moore, 1906), and in the 1960s a team of researchers in the UK and the US independently discovered the incretin effect, in which oral glucose markedly stimulates insulin secretion, setting the stage for the subsequent development of incretin (Elrick et al., 1964

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The pancreas begins to take centre stage Not long after Bernard made his observation, in 1869, Paul Langerhans, a German medical student, made another important discovery while working in the laboratory of Rudolf Virchow, a renowned pathologist and physician at the Berlin Pathological Institute

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