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In the Phase 2 Lancet trial, orforglipron 45 mg reduced HbA1c by up to 2.1 percentage points at 26 weeks, exceeding the reduction achieved by dulaglutide 1.5 mg (the active comparator)
La respuesta depende del resultado clnico especfico que se est evaluando: el control de la glucosa en sangre puede mejorar en 1-2 semanas, mientras que los efectos completos sobre el peso corporal y los beneficios cardiovasculares requieren varios meses de tratamiento continuo
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Incretin based therapies, such as glucagon-like peptide-1 (GLP-1) receptor agonists mimic the hormone that originates from the small intestine and is released in response to nutrition intake
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