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Chemistry of Materials 28 , 40094016, (2016)
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Unloaded drugs and organic solvent were removed through dialysis against deionized water for 48 h
Because SAM is also required for many other methylation reactions, including gene-expression regulation, high NNMT activity draws heavily on SAM and is associated in studies with reduced NAD, a coenzyme central to cellular energy production
Thus, ZZ1 shows preference for targeting a distinct BD compared to most JQ1-based degraders 15,16,32,37 , implying the involvement of a previously unexplored E3 ligase