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The Reuters report on a head-to-head trial against tirzepatide (February 2026) noted CagriSema did not meet a non-inferiority threshold against tirzepatide on average weight loss at 84 weeks

It is also why retatrutide is being studied specifically in metabolic dysfunction-associated steatotic liver disease (MASLD), not just obesity and type 2 diabetes

Increased intestinal permeability is facilitated by a high-fat diet (HFD) 22 , and may allow for bacterial translocation from the gut to adipose tissue 23

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Then, each ring was washed and re-equilibrated for 60 min