doi: 10.1007/s13679-014-0124-9
The GLP-1 medication itselfthe semaglutide (Wegovy, Ozempic) or tirzepatide (Zepbound, Mounjaro) that powers the treatmentis a separate and much larger expense
Early, small trials suggested a beneficial effect of ALCAR with respect to cognitive decline (98-100), whereas later, larger trials found little-to-no effect compared to placebo (101-103)
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In the first sensitivity analysis comparing the risk of incident NAION in persons with T2D treated with SGLT2 inhibitors alone ( n = 40,206, reference), once-weekly semaglutide alone ( n = 71,658), and once-weekly semaglutide and SGLT2 inhibitors combined ( n = 45,401), we observed 6 events in 82,877 person-years, 36 events in 178,868 person-years, and 31 events in 119,106 person-years, respectively, corresponding to adjusted HR of 242 (95% CI 097 606) and 262 (95% CI 102674) for once-weekly semaglutide without and with SGLT2 inhibitors in a multivariable model adjusted for sex, age, marital status, duration of diabetes, hemoglobin A1c, estimated glomerular filtration rate, cardiovascular disease, use of insulin, use of cholesterol-lowering medicine, and use of blood pressure lowering medicine

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