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10.1089/acm.2006.12.881 Summary Keywords vitamin B12, efficacy, bioavailability, therapeutic approaches, meta-analysis, cobalamin Citation Mazur M, Ndokaj A, Salerno C, Vallone J, Ardan R, Bietolini S, Carrouel F, Wilk A, Sarig R, Ottolenghi L and Bourgeois D (2025) Efficacy of sublingual and oral vitamin B12 versus intramuscular administration: insights from a systematic review and meta-analysis
Besides, taking vitamin B12 right before bed can have a negative impact on your sleep due to potential side effects such as headache, anxiety, nausea, and vomiting
It remains under investigation in clinical trials registered on ClinicalTrials.gov and the EU Clinical Trials Register, and is not licensed for prescription or self-administration outside of formally approved research settings
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Vitamin B12 also removes a dangerous protein in the blood called homocysteine that could otherwise damage arteries and contribute to inflammation, osteoporosis, and heart disease
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