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Human research is limited

For instance, the butyrate-producing Butyribacter showed positive correlations with neuroactive metabolites L-Asparagine, while these metabolites exhibited inverse correlations with expression of neuroinflammatory genes Tbx and Arhgdib, demonstrating how tooth loss-induced depletion of Butyribacter led to reduced levels of neuroprotective metabolites (particularly L-Asparagine), which subsequently resulted in upregulation of neuroinflammatory markers (Tbx1 and Arhgdib), thereby establishing a mechanistic pathway from tooth loss to neuroinflammation through the oral-gut-brain axis (Ji et al., 2025)

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Epithalon is investigated for its effects on telomerase activity and telomere maintenance in cellular models

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Cannot be used as a substitute of a healthy and balanced diet