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Abstract Polycystic ovary syndrome (PCOS) is a heterogeneous endocrinemetabolic disorder in which reproductive dysfunction coexists with insulin resistance, chronic low-grade inflammation, and heightened oxidative stress (OS)

Before pursuing B12 injections or other interventions marketed for weight loss, patients should consult their GP for proper assessment, investigation of any underlying medical conditions affecting weight, and discussion of evidence-based treatment options

Patients with a history of pancreatitis should be considered for alternative agents when possible

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