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doi: 10.3390/metabo9070152 66 LocatoV.CiminiS.GaraL

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17 While ERAD was previously thought to be associated with PQC, which safeguards protein maturation, recent studies have demonstrated that ERAD also regulates the abundance of folding-competent proteins as a means to fine-tune key physiological processes, suggesting that ERAD constitutively functions to ensure both protein fidelity and abundance