*Correspondence: Yi Hua, [email protected] This article was submitted to Experimental Pharmacology and Drug Discovery, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers
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15 COVID-19 morbidity and mortality of COVID-19 are due in large part to severe cytokine storm brought on by dysregulated inflammatory immune response and a glutathione deficiency has been associated with more severe clinical manifestations of coronavirus
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Coupled with endogenous reactive oxygen species (ROS) generated as by-products of various cellular processes, strict regulation of antioxidants is critical to maintaining a balanced reduction/oxidation (redox) state
Consequently, disruptions in GSH biosynthesis, utilization, or recycling are hallmarks of oxidative stress and have been implicated in the pathogenesis of aging, neurodegenerative diseases like Parkinsons and Alzheimers, cancer, and various metabolic disorders [37]