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10.1074/jbc.M114.549634[Epub ahead of print]

Kozlovski, P

Resistance training two to three times per week provides the primary signal that tells your body to preserve muscle tissue even in the face of significant caloric deficit

There is also a pill called Contrave, which combines buproprion and naltrexone and is FDA-approved for weight management, with weight loss of up to 8% after a year