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Definition: damage to the myelin sheath of the white matter in the CNS caused by a sudden rise in serum osmolality Central pontine myelinolysis Most common type Affects the central region of the pons Extrapontine myelinolysis: can affect the cerebellum, lateral geniculate body, thalamus, putamen, cortical, and/or subcortical white matter Causes Iatrogenic: rapid correction of chronic hyponatremia High-risk factors for ODS: alcohol use disorder, malnutrition, liver disease, hypokalemia, initial sodium concentration 105 mEq/L [2] Rapid changes in other osmotically active solutes (e.g., glucose) Acute severe hypernatremia Clinical features [30] [31] Symptoms first develop several days after the correction of hyponatremia
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Ozempic should be initiated at a low dose to minimize gastrointestinal symptoms
Meanwhile, BPC-157 sends out protective signals to shield cells from further damage
Injection Site Reactions: Redness or swelling, resolving quickly from local activation
