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35 The exact significance of both the former and the latter in therapeutic terms in the management of hyperpigmentation is unknown except what can be gathered from observational studies

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Am J Prev Med 42(6):563570 Mingrone G, Panunzi S, De Gaetano A et al (2021) Metabolic surgery versus conventional medical therapy in patients with type 2 diabetes: 10-year follow-up of an open-label, single-centre, randomised controlled trial

Nevertheless, FSP1 has been less studied in the heart, where its relationship with ferroptosis and its precise function are poorly understood