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Chem Commun 48:997999
PMID: 26604952
Discovery of IPN60090, a clinical stage selective Glutaminase-1 (GLS-1) inhibitor with excellent Pharmacokinetic and physicochemical properties
Cleavage of Boc groups with 4 M HCl/dioxane followed by a coupling reaction with the -carboxyl group of the N -hydroxysuccinimide active ester of Boc-Glu--OtBu resulted in the corresponding glutathione disulfide-1,1- 13 C with fully protected N and C-terminals
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