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developed multifunctional afterglow nanoscale sensors (MANS) that activate luminescence in response to superoxide, enabling high-contrast off-to-on activation imaging, providing a new strategy for molecular imaging of IRI [134]

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concluded that their results indicated that gliotoxin production is increased to facilitate fungal pathogenicity (mimicking the aerobic lung environment), an alternative conclusion, which is in accordance with our thinking, is that gliotoxin production is actually elevated to cope with increased oxygen levels and that secretion of gliotoxin forms part of the gliotoxin homeostasis control mechanism within A

Future efforts should develop multifunctional integrated smart nanoplatforms that integrate Ca homeostasis regulation, ROS scavenging, and mitochondrial protection to more effectively address the complex pathological processes associated with calcium overload

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On the other hand, due to the important functions played by parasite selenoproteins in their biology (such as modulating the host immune response), they can be also considered as a novel therapeutic strategy by designing specific inhibitors against these important proteins