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The most common side effects were mild to moderate GI problems, which mainly occurred after people first started taking ecnoglutide

Psychiatry International, 5(3), 22

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CMS BALANCE Model The BALANCE Model (announced December 23, 2025) could expand GLP-1 coverage through participating Medicare Part D and Medicaid plans

The good news is that the SURMOUNT-5 trial found no statistically significant difference in GI side effect rates between the two medications at their respective therapeutic doses

In the SURMOUNT-1 clinical trial, participants lost approximately 15-20% of their body weight over 72 weeks, with results varying by dose